
We included all patients with hypertension initiating monotherapy with an ACE inhibitor or ARB between 19 across 8 databases from the United States, Germany, and South Korea. We implemented a retrospective, new-user comparative cohort design to estimate hazard ratios using techniques to minimize residual confounding and bias, specifically large-scale propensity score adjustment, empirical calibration, and full transparency. We compared the real-world effectiveness and safety of ACE inhibitors versus ARBs in the first-line treatment of hypertension.



Arteriosclerosis, Thrombosis, and Vascular Biology (ATVB).
